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Adult Acute Monoblastic Leukemia

MedGen UID:
76004
•Concept ID:
C0279629
•
Neoplastic Process
Synonyms: Adult Acute M5a Leukemia; M5a Adult Acute Leukemia; M5a Adult Acute Poorly Differentiated Monoblastic Leukemia

Definition

An acute monoblastic leukemia occurring in adults. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdult Acute Monoblastic Leukemia

Professional guidelines

PubMed

Myelomonocytic and monocytic acute myeloid leukemia demonstrate comparable poor outcomes with venetoclax-based treatment: a monocentric real-world study.
Zhao L, Yang J, Chen M, Xiang X, Ma H, Niu T, Gong Y, Chen X, Liu J, Wu Y
Ann Hematol 2024 Apr;103(4):1197-1209. Epub 2024 Feb 8 doi: 10.1007/s00277-024-05646-7. PMID: 38329487
LILRB4-targeting Antibody-Drug Conjugates for the Treatment of Acute Myeloid Leukemia.
Anami Y, Deng M, Gui X, Yamaguchi A, Yamazaki CM, Zhang N, Zhang CC, An Z, Tsuchikama K
Mol Cancer Ther 2020 Nov;19(11):2330-2339. Epub 2020 Sep 2 doi: 10.1158/1535-7163.MCT-20-0407. PMID: 32879051Free PMC Article
Proposed diagnostic criteria for classical chronic myelomonocytic leukemia (CMML), CMML variants and pre-CMML conditions.
Valent P, Orazi A, Savona MR, Patnaik MM, Onida F, van de Loosdrecht AA, Haase D, Haferlach T, Elena C, Pleyer L, Kern W, Pemovska T, Vladimer GI, Schanz J, Keller A, Lübbert M, Lion T, Sotlar K, Reiter A, De Witte T, Pfeilstöcker M, Geissler K, Padron E, Deininger M, Orfao A, Horny HP, Greenberg PL, Arber DA, Malcovati L, Bennett JM
Haematologica 2019 Oct;104(10):1935-1949. Epub 2019 May 2 doi: 10.3324/haematol.2019.222059. PMID: 31048353Free PMC Article

Recent clinical studies

Etiology

Feasibility of pevonedistat combined with azacitidine, fludarabine, cytarabine in pediatric relapsed/refractory AML: Results from COG ADVL1712.
Tarlock K, Liu X, Minard CG, Isikwei EA, Reid JM, Horton TM, Fox E, Weigel BJ, Cooper T
Pediatr Blood Cancer 2023 Dec;70(12):e30672. Epub 2023 Sep 14 doi: 10.1002/pbc.30672. PMID: 37710306Free PMC Article
Adult mixed phenotype acute leukemia (MPAL): B/myeloid MPAL(isoMPO) is distinct from other MPAL subtypes.
Weinberg OK, Dennis J, Zia H, Chen P, Chu A, Koduru P, Luu HS, Fuda F, Chen W
Int J Lab Hematol 2023 Apr;45(2):170-178. Epub 2022 Nov 2 doi: 10.1111/ijlh.13988. PMID: 36325594
Extensive Remodeling of the Immune Microenvironment in B Cell Acute Lymphoblastic Leukemia.
Witkowski MT, Dolgalev I, Evensen NA, Ma C, Chambers T, Roberts KG, Sreeram S, Dai Y, Tikhonova AN, Lasry A, Qu C, Pei D, Cheng C, Robbins GA, Pierro J, Selvaraj S, Mezzano V, Daves M, Lupo PJ, Scheurer ME, Loomis CA, Mullighan CG, Chen W, Rabin KR, Tsirigos A, Carroll WL, Aifantis I
Cancer Cell 2020 Jun 8;37(6):867-882.e12. Epub 2020 May 28 doi: 10.1016/j.ccell.2020.04.015. PMID: 32470390Free PMC Article
Proposed diagnostic criteria for classical chronic myelomonocytic leukemia (CMML), CMML variants and pre-CMML conditions.
Valent P, Orazi A, Savona MR, Patnaik MM, Onida F, van de Loosdrecht AA, Haase D, Haferlach T, Elena C, Pleyer L, Kern W, Pemovska T, Vladimer GI, Schanz J, Keller A, Lübbert M, Lion T, Sotlar K, Reiter A, De Witte T, Pfeilstöcker M, Geissler K, Padron E, Deininger M, Orfao A, Horny HP, Greenberg PL, Arber DA, Malcovati L, Bennett JM
Haematologica 2019 Oct;104(10):1935-1949. Epub 2019 May 2 doi: 10.3324/haematol.2019.222059. PMID: 31048353Free PMC Article
Proposals for the classification of the acute leukaemias. French-American-British (FAB) co-operative group.
Bennett JM, Catovsky D, Daniel MT, Flandrin G, Galton DA, Gralnick HR, Sultan C
Br J Haematol 1976 Aug;33(4):451-8. doi: 10.1111/j.1365-2141.1976.tb03563.x. PMID: 188440

Diagnosis

Feasibility of pevonedistat combined with azacitidine, fludarabine, cytarabine in pediatric relapsed/refractory AML: Results from COG ADVL1712.
Tarlock K, Liu X, Minard CG, Isikwei EA, Reid JM, Horton TM, Fox E, Weigel BJ, Cooper T
Pediatr Blood Cancer 2023 Dec;70(12):e30672. Epub 2023 Sep 14 doi: 10.1002/pbc.30672. PMID: 37710306Free PMC Article
Neutrophilic Eccrine Hidradenitis.
Beatty CJ, Ghareeb ER
N Engl J Med 2021 Aug 5;385(6):e19. doi: 10.1056/NEJMicm2101571. PMID: 34347955
Monocytic Subclones Confer Resistance to Venetoclax-Based Therapy in Patients with Acute Myeloid Leukemia.
Pei S, Pollyea DA, Gustafson A, Stevens BM, Minhajuddin M, Fu R, Riemondy KA, Gillen AE, Sheridan RM, Kim J, Costello JC, Amaya ML, Inguva A, Winters A, Ye H, Krug A, Jones CL, Adane B, Khan N, Ponder J, Schowinsky J, Abbott D, Hammes A, Myers JR, Ashton JM, Nemkov T, D'Alessandro A, Gutman JA, Ramsey HE, Savona MR, Smith CA, Jordan CT
Cancer Discov 2020 Apr;10(4):536-551. Epub 2020 Jan 23 doi: 10.1158/2159-8290.CD-19-0710. PMID: 31974170Free PMC Article
Proposed diagnostic criteria for classical chronic myelomonocytic leukemia (CMML), CMML variants and pre-CMML conditions.
Valent P, Orazi A, Savona MR, Patnaik MM, Onida F, van de Loosdrecht AA, Haase D, Haferlach T, Elena C, Pleyer L, Kern W, Pemovska T, Vladimer GI, Schanz J, Keller A, Lübbert M, Lion T, Sotlar K, Reiter A, De Witte T, Pfeilstöcker M, Geissler K, Padron E, Deininger M, Orfao A, Horny HP, Greenberg PL, Arber DA, Malcovati L, Bennett JM
Haematologica 2019 Oct;104(10):1935-1949. Epub 2019 May 2 doi: 10.3324/haematol.2019.222059. PMID: 31048353Free PMC Article
Proposals for the classification of the acute leukaemias. French-American-British (FAB) co-operative group.
Bennett JM, Catovsky D, Daniel MT, Flandrin G, Galton DA, Gralnick HR, Sultan C
Br J Haematol 1976 Aug;33(4):451-8. doi: 10.1111/j.1365-2141.1976.tb03563.x. PMID: 188440

Therapy

Feasibility of pevonedistat combined with azacitidine, fludarabine, cytarabine in pediatric relapsed/refractory AML: Results from COG ADVL1712.
Tarlock K, Liu X, Minard CG, Isikwei EA, Reid JM, Horton TM, Fox E, Weigel BJ, Cooper T
Pediatr Blood Cancer 2023 Dec;70(12):e30672. Epub 2023 Sep 14 doi: 10.1002/pbc.30672. PMID: 37710306Free PMC Article
Neutrophilic Eccrine Hidradenitis.
Beatty CJ, Ghareeb ER
N Engl J Med 2021 Aug 5;385(6):e19. doi: 10.1056/NEJMicm2101571. PMID: 34347955
Monocytic Subclones Confer Resistance to Venetoclax-Based Therapy in Patients with Acute Myeloid Leukemia.
Pei S, Pollyea DA, Gustafson A, Stevens BM, Minhajuddin M, Fu R, Riemondy KA, Gillen AE, Sheridan RM, Kim J, Costello JC, Amaya ML, Inguva A, Winters A, Ye H, Krug A, Jones CL, Adane B, Khan N, Ponder J, Schowinsky J, Abbott D, Hammes A, Myers JR, Ashton JM, Nemkov T, D'Alessandro A, Gutman JA, Ramsey HE, Savona MR, Smith CA, Jordan CT
Cancer Discov 2020 Apr;10(4):536-551. Epub 2020 Jan 23 doi: 10.1158/2159-8290.CD-19-0710. PMID: 31974170Free PMC Article
Acute monoblastic leukemia with t(10;11)(p12;q23) presenting with pulmonary involvement: a case report and literature review.
Prayongratana K, Kulpraneet M, Panichchob P, Tantisiriwat W
J Med Assoc Thai 2008 Apr;91(4):559-63. PMID: 18556867
Aleukemic leukemia cutis.
Ohno S, Yokoo T, Ohta M, Yamamoto M, Danno K, Hamato N, Tomii K, Ohno Y, Kobashi Y
J Am Acad Dermatol 1990 Feb;22(2 Pt 2):374-7. doi: 10.1016/0190-9622(90)70052-j. PMID: 2406302

Prognosis

Clinical and Molecular Approach to Adult-Onset, Neoplastic Monocytosis.
Shallis RM, Siddon AJ, Zeidan AM
Curr Hematol Malig Rep 2021 Jun;16(3):276-285. Epub 2021 Apr 22 doi: 10.1007/s11899-021-00632-6. PMID: 33890194
Bone Marrow Necrosis in Acute Monoblastic Leukemia.
Terao T, Matsue K
N Engl J Med 2021 Feb 18;384(7):650. doi: 10.1056/NEJMicm2026508. PMID: 33596359
Extensive Remodeling of the Immune Microenvironment in B Cell Acute Lymphoblastic Leukemia.
Witkowski MT, Dolgalev I, Evensen NA, Ma C, Chambers T, Roberts KG, Sreeram S, Dai Y, Tikhonova AN, Lasry A, Qu C, Pei D, Cheng C, Robbins GA, Pierro J, Selvaraj S, Mezzano V, Daves M, Lupo PJ, Scheurer ME, Loomis CA, Mullighan CG, Chen W, Rabin KR, Tsirigos A, Carroll WL, Aifantis I
Cancer Cell 2020 Jun 8;37(6):867-882.e12. Epub 2020 May 28 doi: 10.1016/j.ccell.2020.04.015. PMID: 32470390Free PMC Article
Proposed diagnostic criteria for classical chronic myelomonocytic leukemia (CMML), CMML variants and pre-CMML conditions.
Valent P, Orazi A, Savona MR, Patnaik MM, Onida F, van de Loosdrecht AA, Haase D, Haferlach T, Elena C, Pleyer L, Kern W, Pemovska T, Vladimer GI, Schanz J, Keller A, Lübbert M, Lion T, Sotlar K, Reiter A, De Witte T, Pfeilstöcker M, Geissler K, Padron E, Deininger M, Orfao A, Horny HP, Greenberg PL, Arber DA, Malcovati L, Bennett JM
Haematologica 2019 Oct;104(10):1935-1949. Epub 2019 May 2 doi: 10.3324/haematol.2019.222059. PMID: 31048353Free PMC Article
Genomic determinants of chronic myelomonocytic leukemia.
Patel BJ, Przychodzen B, Thota S, Radivoyevitch T, Visconte V, Kuzmanovic T, Clemente M, Hirsch C, Morawski A, Souaid R, Saygin C, Nazha A, Demarest B, LaFramboise T, Sakaguchi H, Kojima S, Carraway HE, Ogawa S, Makishima H, Sekeres MA, Maciejewski JP
Leukemia 2017 Dec;31(12):2815-2823. Epub 2017 May 30 doi: 10.1038/leu.2017.164. PMID: 28555081Free PMC Article

Clinical prediction guides

Myelomonocytic and monocytic acute myeloid leukemia demonstrate comparable poor outcomes with venetoclax-based treatment: a monocentric real-world study.
Zhao L, Yang J, Chen M, Xiang X, Ma H, Niu T, Gong Y, Chen X, Liu J, Wu Y
Ann Hematol 2024 Apr;103(4):1197-1209. Epub 2024 Feb 8 doi: 10.1007/s00277-024-05646-7. PMID: 38329487
Feasibility of pevonedistat combined with azacitidine, fludarabine, cytarabine in pediatric relapsed/refractory AML: Results from COG ADVL1712.
Tarlock K, Liu X, Minard CG, Isikwei EA, Reid JM, Horton TM, Fox E, Weigel BJ, Cooper T
Pediatr Blood Cancer 2023 Dec;70(12):e30672. Epub 2023 Sep 14 doi: 10.1002/pbc.30672. PMID: 37710306Free PMC Article
Clinical and biological impact of ATP-binding cassette transporter activity in adult acute myeloid leukemia.
Sourdeau E, Suner L, Memoli M, Genthon A, Feger F, Soret L, Abermil N, Heuberger L, Bilhou-Nabera C, Guermouche H, Favale F, Lapusan S, Chaquin M, Hirschauer C, Mohty M, Legrand O, Delhommeau F, Hirsch P
Haematologica 2023 Jan 1;108(1):61-68. doi: 10.3324/haematol.2022.280676. PMID: 35924580Free PMC Article
Clinical and Molecular Approach to Adult-Onset, Neoplastic Monocytosis.
Shallis RM, Siddon AJ, Zeidan AM
Curr Hematol Malig Rep 2021 Jun;16(3):276-285. Epub 2021 Apr 22 doi: 10.1007/s11899-021-00632-6. PMID: 33890194
Extensive Remodeling of the Immune Microenvironment in B Cell Acute Lymphoblastic Leukemia.
Witkowski MT, Dolgalev I, Evensen NA, Ma C, Chambers T, Roberts KG, Sreeram S, Dai Y, Tikhonova AN, Lasry A, Qu C, Pei D, Cheng C, Robbins GA, Pierro J, Selvaraj S, Mezzano V, Daves M, Lupo PJ, Scheurer ME, Loomis CA, Mullighan CG, Chen W, Rabin KR, Tsirigos A, Carroll WL, Aifantis I
Cancer Cell 2020 Jun 8;37(6):867-882.e12. Epub 2020 May 28 doi: 10.1016/j.ccell.2020.04.015. PMID: 32470390Free PMC Article

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